Atletico Madrid were handed a chance to avenge last season's Champions League final defeat by city rivals and record 10-times winners Real after the two sides were drawn together in the last eight on Friday. Paris St Germain and Barcelona were paired together having met in the group stage, with the French side winning in Paris and the Catalans coming out on top in Spain.
La Liga leaders Real Madrid dropped points at home for only the second time this season.
In other European football action Real Madrid were left frustrated after a goalless draw against Athletic Bilbao in their La Liga match on Sunday.
Lionel Messi notched his 250th La Liga goal to move one off the all-time league scoring record as leaders Barcelona won 3-0 against Eibar on Saturday ahead of next weekend's Clasico with Real Madrid.
English football's biggest club seem to have secured the services of the sport's most colourful manager after Jose Mourinho, according to Sky TV reports, agreed personal terms with Manchester United on Tuesday.
Lionel Messi netted the 400th goal of his storied career on Saturday as Barcelona trounced Granada 6-0 to maintain the pace at the top of La Liga.
Cristiano Ronaldo opened the scoring as Juventus beat visiting Bologna 2-1 on Saturday to move four points clear at the top of the Serie A table. Ronaldo struck from close range after 19 minutes, but Danilo levelled for the visitors soon afterwards.
Premier League leaders Manchester City won their derby with United 3-1, while Liverpool kept pace with a home win over Fulham.
Images from soccer matches played across different leagues in Europe on Sunday
Manchester United eased the pressure on manager Ole Gunnar Solskjaer with a 3-1 win at Everton in the Premier League on Saturday with Bruno Fernandes scoring twice and Edinson Cavani grabbing his first for the club.
News of all that's transpired on and off the football field
Cristiano Ronald headed his 300th goal for Real Madrid in a laboured 2-0 La Liga victory at neighbours Rayo Vallecano on Wednesday that kept the gap on leaders Barcelona down to four points.
Real Madrid returned to winning ways after last weekend's drubbing at Atletico but failed to convince and were whistled by their own fans during a drab 2-0 victory at home to Deportivo La Coruna on Saturday.
Portugal forward Cristiano Ronaldo won the FIFA Ballon d'Or award for the second year running and the third overall on Monday after a prolific, trophy-filled year with Real Madrid.
Manchester City's quadruple bid remained intact as Ilkay Gundogan and Kevin de Bruyne secured a 2-0 win at Everton in their FA Cup quarter-final clash
Liverpool's defence of a Premier League crown won at a canter last season has become a nightmare
Barcelona followed up last weekend's 3-1 defeat at Real Madrid with another reverse on Saturday, squandering a host of chances to lose 1-0 at home to Celta Vigo and handing the lead in La Liga to their arch rivals.
Clashes between Real Madrid and Barcelona are rarely short on drama and Saturday's La Liga 'Clasico' may have more than its usual share with Luis Suarez poised to return from a biting ban and Barca teammate Lionel Messi on the brink of equalling the top-flight scoring record.
Images from the English Premier League matches played on Wednesday.
Paris St Germain suffered their first defeat of the season when they were beaten 2-0 at Stade Rennais on Sunday to drop their first Ligue 1 points of the season.
Roma teenager Afena-Gyan plays down apparent racist remark.
Arsenal will have to produce the biggest second leg comeback in a Champions League knockout tie to avoid a seventh successive exit at the last 16 stage when they host Bayern Munich on Tuesday.
Christian Eriksen kept Tottenham Hotspur's hopes of completing a remarkable salvage job and reaching the last 16 of the Champions League alive with a late winner in his side's 1-0 victory over Inter Milan at Wembley on Wednesday.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
As Leicester City celebrates its unexpected title triumph, Bikash Mohapatra/Rediff.com lists similar success stories across Europe's top leagues.
In Maximum City as the Wellness Ambassador of Kanakia Paris, a French-themed residential complex, the French football icon opened up about Real Madrid, Euro 2016 and the current France team among other topics. Bikash Mohapatra/Rediff.com was all ears.
Lionel Messi was in inspired form as champions Barcelona hammered Celta Vigo 5-0 on Saturday, recording a fourth straight league victory which keeps them top of La Liga after Real Madrid had put the pressure on the Catalans with a 4-1 win at Eibar.
Toni Kroos netted his first for Real Madrid and was hailed as the best player on the pitch by his coach as the hosts tore apart Rayo Vallecano 5-1 in La Liga on Saturday to extend their winning streak to 13 games.
Many former players believe that storming out of games is a powerful tool to counter racism, a move that will force administrators to take the problem more seriously, and act in a way that compels clubs to obliterate such a culture and evict those responsible, says Dhruv Munjal.
Juventus rehire Allegri.
News of all that's transpired on and off the football field.
News of all that's transpired on and off the football field
Raheem Sterling struck twice as the Premier League champions Manchester City beat Crystal Palace 3-1 at Selhurst Park on Sunday to stay within two points of leaders Liverpool.
Inter Milan staged a late smash-and-grab raid as goals by Mauro Icardi and Matias Vecino secured a 2-1 home win over Tottenham Hotspur in their Champions League Group B opener on Tuesday.
Real Madrid earned their first-ever win over Liverpool with a wondrous Cristiano Ronaldo goal spearheading a 3-0 Champions League victory at Anfield on Wednesday which appeared as classy as it was dominant.
Paulo Dybala came off the bench to give unbeaten Serie A leaders Juventus a 1-0 win away to a brave Bologna side who had the better of the match and hit the post in stoppage time on Sunday.
A summary of Wednesday's matches in the UEFA Champions League.
English Premier League leaders Liverpool opened up a 22-point gap at the top of the table with second-half goals from Alex Oxlade-Chamberlain, Jordan Henderson and a Mohamed Salah brace giving them a 4-0 home win over Southampton. A rare double from defender Antonio Rudiger earned Chelsea a point in an entertaining 2-2 draw with third-placed Leicester City.
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